Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans

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Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans.

Glucose tolerance is lower in the evening and at night than in the morning. However, the relative contribution of the circadian system vs. the behavioral cycle (including the sleep/wake and fasting/feeding cycles) is unclear. Furthermore, although shift work is a diabetes risk factor, the separate impact on glucose tolerance of the behavioral cycle, circadian phase, and circadian disruption (i....

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Circadian misalignment increases cardiovascular disease risk factors in humans.

Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors. One of the key features of shift workers is that their behavioral and environmental cycles are typically misaligned relative to their endogenous circadian system. However, there is little information on the impact of acute circadian misal...

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Circadian misalignment and sleep disruption in mild cognitive impairment.

BACKGROUND While it is evident that Alzheimer's disease is associated with disturbed sleep and circadian rhythms, the extent to which such changes are evident in older people 'at risk' of developing dementia is unknown. OBJECTIVE In this study, we aimed to determine whether patients with mild cognitive impairment (MCI) demonstrated significant alterations in the timing of melatonin secretion ...

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Diabetic Autonomic Neuropathy and Circadian Misalignment in Type 1 Diabetes

Misalignment of circadian rhythms has been evidenced in patients with type 1 diabetes and there is a close relationship between alterations in neuroendocrine sleep architecture, circa‐ dian clock oscillations, glucose metabolism, autonomic function, and diurnal profiles of blood pressure and heart rate [1-5]. In turn, circadian misalignment may modify the peak incidence of cardiovascular events...

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Extraocular circadian phototransduction in humans.

Physiological and behavioral rhythms are governed by an endogenous circadian clock. The response of the human circadian clock to extraocular light exposure was monitored by measurement of body temperature and melatonin concentrations throughout the circadian cycle before and after light pulses presented to the popliteal region (behind the knee). A systematic relation was found between the timin...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2015

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1418955112